ACTA MEDICA
ACTA MEDICA
Acta Medica (Hradec Králové) is an English language multidisciplinary medical journal. Acta Medica publishes reviews, original articles, brief communications, case reports, announcements, and notices. The journal was founded in 1958 under the title “A Collection of Scientific Works of the Charles University’s Faculty of Medicine in Hradec Králové”. The journal is indexed in Chemical Abstracts, CNKI, DOAJ, EBSCO, Hinari, Index Medicus, MEDLINE, Scopus, and Ulrichsweb.

ACTA MEDICA, Vol 60 No 4 (2017), 152–156

Treatment of Multifocal Multisystem BRAF positive Langerhans Cell Histiocytosis with Cladribine, surgery and Allogenic Stem Cell Transplantation

Filip Gabalec, Martin Šimkovič, Alžběta Zavřelová, Petra Kašparová, Paula Morávková, Marcela Kopáčová, Václav Masopust, Pavel Žák, Jan Čáp, Jakub Radocha

DOI: https://doi.org/10.14712/18059694.2018.11
published online: 23. 04. 2018

abstract

Langerhans cell histiocytosis (LCH) is a very rare disease in adults and as well a very rare cause of sellar expansion. The clinical presentation can be heterogeneous, from a single bone lesion to potentially fatal, widespread disease. We describe the difficulties with the diagnosis and treatment of LCH as well as successful treatment with cladribine chemotherapy and allogeneic stem cell transplantation.

keywords: histiocytosis; transplantation; stem cell; cladribine; hypopituitarism

Creative Commons License
Treatment of Multifocal Multisystem BRAF positive Langerhans Cell Histiocytosis with Cladribine, surgery and Allogenic Stem Cell Transplantation is licensed under a Creative Commons Attribution 4.0 International License.

210 x 297 mm
periodicity: 4 x per year
print price: 150 czk
ISSN: 1211-4286
E-ISSN: 1805-9694

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