Homer Wells' odyssey begins among the apple orchards of rural Maine. As the oldest unadopted child at St Cloud's orphanage, he strikes up a profound and unusual friendship with Wilbur Larch, the orphanage's founder - a man of rare compassion and an addiction to ether. What he learns from Wilbur takes him from his early apprenticeship in the orphanage surgery, to an adult life running a cider-making factory and a strange relationship with the wife of his closest friend...